TY - JOUR T1 - Impact of three back-up rate (BUR) on subjective quality of sleep (QoS) and residual events in obesity-hypoventilation (OHS) treated by home non invasive ventilation (NIV): A randomised controlled trial JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - 1436 AU - Olivier Contal AU - Jean-Christian Borel AU - Dan Adler AU - Fabrice Espa AU - Daniel Rodenstein AU - Jean-Louis Pépin AU - Jean-Paul Janssens Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/1436.abstract N2 - Introduction: NIV is widely used to treat OHS. There is however no evidence in the literature for defining optimal BUR.Aim of study: To compare the impact of spontaneous ventilation (SV; BUR=0), low BUR (10.9±0.9/min) and high BUR (20.5±1.5/min) applied in random order during 3 consecutive nights in OHS patients. Main outcome: Sleep structure assessed PSG Secondary outcome: Hypoventilation and residual events.Methods: Polysomnography were scored for sleep structure, obstructive (OE), central (CE) and mixed (ME) respiratory events,% time spent with patient ventilator asynchrony (PVA) and nocturnal hypoventilation meaured by TcPCO2. Two questionnaires assessed subjective QoS.Results: Ten stable OHS patients under long term NIV (mean±SD; aged 55.7±9.2 yrs; BMI 48.5±5 kg/m2, PaCO2: 5.5±0.7 kPa) were included. Table 1 depicts main results.ODI, CE, ME and time spent with PVA were all much higher with SV than with either low or high BUR. Subjective QoS did not differ between SV and low BUR. However subjects with high BUR perceived more awakenings and a lower QoS than with low BUR whereas their Sleep efficiency was lower.Conclusion: In stable OHS patients under long term NIV, SV was associated with a very high rate of ODI, CE and ME when compared to low and high BUR. High BUR was perceived as less comfortable than low BUR. ER -