TY - JOUR T1 - Genetic typing of bronchial asthma afflicted people according to polymorphous genes for the purpose of disease progress risk factors detection JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p717 AU - Natalia Dudareva Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p717.abstract N2 - The article presents the data concerning frequency allocation.of gaplotypes and alleles of genes belonging to family glutathione-S-transferase (GSTM and GSTT), genes of cytokines (IL-6 and TNF-A), cytotoxic receptor of T-lymphocyte gene (CTLA-4) and gene of vitamin D receptor in case of afflicted people with uncontrolled bronchial asthma clinical course. The data are compared to the frequency allocation of gaplotypes and alleles of the foregoing genes in the citizens' population in different areas of Belarus. The received data concerning the frequency allocation of gaplotypes and alleles of genes CTLA-4, TNF-A, GSTM and GSTT didn't authentically differ from the frequency of Belarusian population. No authentic frequency allocation differences were detected. However there were authentically proved differences in frequency allocation of gaplotypes and alleles of genes between four polymorphous locuses of VDR-gene in case of bronchial asthma afflicted people from the one detected in the population. The VDR gene's frequency of homozygotes FF at FokI locus (36,0%) is higher than the population's one (29,1%). The VRD gaplotype TtAaBbFF appeared to be the bronchial asthma afflicted people's most spread one (17,4%) (in Belarusians' population selection the most spread gaplotype is TtAaBbFf). The received data indicate the connection of VDR- polymorphism with uncontrolled bronchial asthma and the utility of conducting the further research concerning the influence of vitamin D on treatment. ER -