TY - JOUR T1 - Imaging techniques in the evaluation of solitary pulmonary nodules (SPNs) JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p3662 AU - Marta Dabrowska AU - Rafal Krenke AU - Piotr Korczynski AU - Marta Maskey-Warzechowska AU - Malgorzata Zukowska AU - Jolanta Kunikowska AU - Wlodzimierz Kupis AU - Ryszarda Chazan Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p3662.abstract N2 - Despite new imaging techniques such as contrast enhanced computed tomography (CECT) or positron emission tomography with 18-fluorodeoxyglucose (FDG-PET/CT), non-invasive diagnosis of SPN etiology still remains a problem.Aim: 1. to assess the incidence of maligancy in newly diagnosed SPNs2. to evaluate utility of CECT and FDG-PET/CT in SPN diagnosisMethods: 85 patients with newly diagnosed SPNs were observed on an ambulatory basis between 2008 and 2010.The diagnosis of malignant etiology of SPNs was based on pathological examination.The benign etiology was proved based on either:1. pathological examination2. lack of growth for at least 2 years or resolution in radiological follow-up3. central/total calcification in CTThe result of FDG PET/CT was suggestive for benign etiology of SPN if uptake of FDG was like background (SUV < 1) and the result of CECT -if enhancement value was < 15HU.Results: The SPN etiology was determined in 60 patients. 12 nodules (14%) were malignant. 48 nodules (56.5%) were benign. 17 patients are still under observation; 8 were lost to follow up.FDG-PET/CT was performed in 32 patients. In 16 cases the result was negative, 12 had an increased FDG uptake, 4 were inconclusive. The sensitivity, specificity, positive (PPV)and negative predicative value (NPV) and diagnostic accuracy of FDG-PET/CT were 91%, 87%, 83%, 93% and 88%, respectively.CECT was performed in 26 patients. In 10 cases the result was suggestive for benign SPN. The sensitivity, specificity, PPV, NPV and diagnostic accuracy of CECT were 100%, 48%, 69%, 100%, and 58% respectively.Conclusions: The diagnostic accuracy of FDG-PET/CT is higher than that of CECT. The advantage of CECT is its high sensitivity and NPV. ER -