TY - JOUR T1 - Predicting survival in pulmonary hypertension in the United Kingdom: Comparison of prognostic equations JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - 4915 AU - Wai-Ting Nicola Lee AU - Yi Ling AU - Karen Sheares AU - Joanna Pepke-Zaba AU - Andrew Peacock AU - Martin Johnson Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/4915.abstract N2 - Background: Prognostic equations in pulmonary arterial hypertension (PAH) have been developed in the United States [1,2] and France [3]. It is not known if these would perform as well in the United Kingdom (UK) as a locally derived scoring scheme.Aims: To develop and validate a UK composite score (CS) to predict prognosis in pre-capillary pulmonary hypertension (PCPH).Methods: The CS was derived from 209 patients with PCPH (except congenital heart disease) treated in the Scottish Pulmonary Vascular Unit (2000-09) by including independent baseline prognostic variables identified in multivariate Cox analysis. Brier scores (BS) were used to compare its performance with other equations in 121 patients with PCPH treated at Papworth Hospital, UK. Superior performance was indicated by a lower BS.Results:View this table:Table 1. CSThe risk of death increased with CS in the Papworth cohort (HR 1.5, p<0.0001). The CS had a significantly lower BS than REVEAL1 (0.096 vs 0.114) and French Registry3 equations (0.096 vs 0.126) at 1 year, and French Registry equation3 (0.153 vs 0.200) at 2 years.Conclusions: The CS predicts survival and appears to be superior to other equations in an independent UK cohort.References:1. Benza et al. Circulation 2010.2. Thenappan et al. ERJ 2010.3. Humbert et al. ERJ 2010. ER -