RT Journal Article
SR Electronic
T1 K-edge subtraction (KES) synchrotron imaging allows quantitative measurement of regional aerosol deposition, lung ventilation and airway morphology in rabbit
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4876
VO 38
IS Suppl 55
A1 Sam Bayat
A1 Loïc Degrugilliers
A1 Liisa Porra
A1 Gergely Albu
A1 Heikki Suhonen
A1 Satu Strengell
A1 Gergely Fodor
A1 Ferenc Petak
A1 Pekka Suortti
A1 Walid Habre
A1 Anssi R.A. Sovijärvi
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/4876.abstract
AB Rationale: The simultaneous measurement of regional lung ventilation, aerosol deposition and the anatomic configuration of airways are crucial for the better understanding of the determinants of aerosol deposition heterogeneity. However, no single imaging modality currently allows the acquisition of all such data simultaneously. The goal of this study was to test the feasibility of KES imaging to this end.Methods: We used KES synchrotron radiation imaging [AJRCCM, 2009;180:296–303] to quantify regional lung ventilation, and the deposition of iodine (Iomeprol 88 mg/ml in NaCl 0.9%), delivered using an ultrasonic nebulizer (mass median aerodynamic diameter: 2.6±0.1 μm), in a healthy anesthetized, and mechanically ventilated rabbit (2.8 kg) in upright position. Regional ventilation images were obtained in 4 axial slices during inhalation of 70% Xe in O2. Regional iodine deposition images were obtained in 45 contiguous slices after 0, 5, 10, 15 and 20 minutes of nebulization.Results: See figure. Aerosol deposition showed significant spatial heterogeneity in normal lung. Inset: 3D rendering of central conducting airways (dark) and iodine (medium) and parenchyma (light grey).Conclusions: These data demonstrate the feasibility of K-edge subtraction imaging for the quantitative measurement of regional aerosol deposition, lung ventilation and airway morphology in vivo.