PT - JOURNAL ARTICLE AU - John Widger AU - Mark Oliver AU - Fergus Cameron AU - Sarath Ranganathan AU - Phil Robinson TI - Glucose tolerance during pulmonary exacerbations in children with cystic fibrosis DP - 2011 Sep 01 TA - European Respiratory Journal PG - p4555 VI - 38 IP - Suppl 55 4099 - http://erj.ersjournals.com/content/38/Suppl_55/p4555.short 4100 - http://erj.ersjournals.com/content/38/Suppl_55/p4555.full SO - Eur Respir J2011 Sep 01; 38 AB - Introduction: Patients with cystic fibrosis (CF) and normal glucose tolerance (NGT) may exhibit diabetic glucose tolerance during pulmonary exacerbations [1].Aims: We examined glucose tolerance during exacerbations in children with CF and compared continuous glucose monitoring (CGM) with the gold standard oral glucose tolerance test (OGTT).Methods: Children with CF aged at least 10 years hospitalised with an exacerbation were recruited. Those with diabetes and those on corticosteroids were excluded. On admission, patients had an OGTT and were fitted with a CGM for 3 days. Six weeks post discharge both tests were repeated.Results: Ten patients (3 males), mean age 13.9 years, have completed the study. Two patients had CGM alone, 4 patients had OGTT alone and 4 patients had both tests. By OGTT criteria, 3 were diabetic, 3 had NGT and 2 had impaired glucose tolerance (IGT) during exacerbations. Glucose tolerance status did not change between exacerbation and follow-up although mean 2-hour glucose fell from 9.7 mmol/l to 8.6 mmol/l on repeat testing (p=0.012). For CGM (n=6), mean time spent with glucose > 7.8mmol/l fell from 7% during exacerbation to 4.3% when well (p=0.24). All 3 patients with NGT and 1 with IGT on OGTT had transient hyperglycaemia ≥11.1 mmol/l on CGM during exacerbations.Conclusions: In contrast to previous published research, we found that glucose tolerance status, as determined by OGTT, remains unchanged during exacerbations. Patients with NGT and IGT had transient hyperglycemia on CGM.Reference:1. Sc NN, Shoseyov D, Kerem E, Zangen DH. Patients with cystic fibrosis and normoglycemia exhibit diabetic glucose tolerance during pulmonary exacerbation. J Cyst Fibros May;9(3):199-204.