TY - JOUR T1 - Interrelations between brainstem auditory evoked potential and visual evoked potential abnormalities in stable COPD patients JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p4066 AU - Prem Parkash Gupta AU - Sushma Sood AU - Atulya Atreja AU - Dipti Agarwal Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p4066.abstract N2 - Background: COPD is presently regarded as a multi-system disorder having significant extra-pulmonary manifestations in addition to its pulmonary components.Objectives: To assess brainstem auditory evoked potential [BAEP] and visual evoked potential [VEP] abnormalities in stable COPD patients, and to evaluate for any interrelations between them.Methods: Eighty male subjects were included: 40 stable COPD patients with no clinical neuropathy, and 40 age-matched healthy volunteers [HV]. For BAEP evaluation, latencies of waves I, II, III, IV and V along with interpeak latencies [IPL] of I-III, I-V and III-V, and amplitudes I-Ia and V-Va were studied. For VEP analysis, latency and amplitude of P100 wave were assessed. Significant abnormality was defined as a variation beyond HV mean ± 3 SD.Results: Twenty-six COPD patients had BAEP abnormalities: prolongation in latencies wave III [50%] and wave V [37.5%], increased IPL I-V [45%] and IPL I-III [35%], and decrease in amplitudes V-Va [17.5%] and I-Ia [5%]. VEP abnormalities were observed in 23 patients: prolongation in latency P100 wave (55%), and decrease in amplitude P100 wave (7.5%). Evaluations for interrelations between BAEP and VEP variables showed latency P100 [left] correlated with latencies wave I and III [both sides] and IPL I-III [right]. Amplitude P100 [right] correlated with amplitude I-Ia [right] and V-Va [both sides]. Amplitude P100 [left] correlated with amplitude I-Ia [right] and amplitude V-Va [right].Conclusions: A significant number of stable COPD patients had BAEP as well as VEP abnormalities and, also, many of these BAEP and VEP abnormalities were interrelated. ER -