RT Journal Article SR Electronic T1 Association of inflammation and bronchial hyperresponsiveness JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP p4543 VO 38 IS Suppl 55 A1 Irina Trofimenko A1 Boris Chernyak YR 2011 UL http://erj.ersjournals.com/content/38/Suppl_55/p4543.abstract AB Bronchial hyperresponsiveness (BHR) is known to be linked to decline in lung function, only limited data are available as to whether BHR is associated with systemic inflammation in COPD.Aim: To compare serum biomarkers of patients with COPD and chronic bronchitis (CB) and to assess local and systemic inflammation in COPD depending on BHR.Methods: At 59 outpatients (50-COPD II st and 9-CB) with smoking more 10 pack/years serum concentrations IL-6, IL-8, TNF-a, CRP were analyzed. BHR was assessed in metacholine challenge. Induced sputum samples were obtained from 42 COPD patients.Results: Serum IL-6 and IL-8 in COPD patients were higher in comparison to CB patients: the medians difference was 1,44 pg/ml and 2,10 pg/ml, respectively (p<0,05). Levels TNF-a, CRP were higher in COPD patients, but did not reach statistical significance. Among CB patients BHR revealed at 1 of 9. Among COPD patients BHR revealed at 31 of 50 (62%). The pack/years were comparable in CB and COPD patients.Serum IL-6 and IL-8 in COPD patients with BHR were higher in comparison to COPD patients without BHR: the means difference was 2,80 and 2,67 pg/ml, respectively (p<0,05). There were not differences between TNF-a and CRP in COPD patients depending on BHR.COPD patients with BHR had significantly higher numbers of total cell counts and macrophages in induced sputum than COPD patients without BHR: 3,63 vs 2,30×106 cells mL-1 and 1,31 vs 0,37×106 cells mL-1 (p<0,01). No differences were found for FEV1 and pack/years in COPD patients.Conclusion: Serum biomarkers at COPD patients with BHR were considerably higher in comparison to CB and COPD patients without BHR. BHR in COPD is associated with more intensive local airway and systemic inflammation.