TY - JOUR T1 - Cellular atypia and lung cancer JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p2815 AU - Carla Antόnio AU - Filomena Luís AU - Silvia Correia AU - Nuno Sousa AU - Luís Ferreira Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p2815.abstract N2 - Introduction: The diagnosis of lung cancer based on imaging and the cytology of sputum, have shown insufficient as for the supervened one. The objective of the work is to describe the clinical profile of patients with atypia the cytology of bronchial aspirated.Methodology: Two groups of patients according to the presence or not of atypia in bronchial lavage. It was proceeded the mating intergroups by sex and age. Variables: smoking, comorbidity, alterations imagiologic, bacteriology, endoscopic findings and indication for the fiber optic bronchoscopy (BFC).Results: Each group with 108 patients, media age of 71.6±4.2 years, being 86 males and 22 women. In the group with atypia 61.1% of patients were smokers or ex-smokers, 38.9% in the group without atypia. In the group with atypia 48.1% had Chronic Obstructive Pulmonary Disorder (COPD) and in the group without atypia 28.7%. The neoplasia in another body was present in 29.6%, in the group with atypia and 13.9% in the group without atypia. The test of χ2 showed dependence between atypia and smoking and these comorbilidades. In situations of atypia 38 patients were new cytology, 13.2% maintained atypia, without evidence of disease neoplastic/infectious.Conclusions: The atypia is associated with smoking, COPD and presence of neoplasia in another body, which are risk factors for lung cancer. The persistence of atypia isolated in bronchial lavage with computed tomography, in the BFC of white light normal, may justify the use of BFC of autoflurescence and ecobronchoscopy (EBUS), effective techniques for detection of lesions pre-neoplastic. Prospective studies will be necessary to determine the conduct proper, in situations of persistence of atypia without identification of lesion. ER -