@article {Zulkarneevp496, author = {Rustem Zulkarneev and Shamil Zagidullin and Marsel Sadritdinov and Usman Farhutdinov and Veronika Leshkova and Natalia Vlasova and Venera Mustafina}, title = {Arterial hypoxemia and diminished immune response at admission predict poor outcome in patients with viral-bacterial pneumonia during flu H1N1 pandemic period}, volume = {38}, number = {Suppl 55}, elocation-id = {p496}, year = {2011}, publisher = {European Respiratory Society}, abstract = {Severe flu associated respiratory infections remain actual.Aim: To evaluate the prognostic model of outcome of severe viral-bacterial community acquired pneumonia (VBCAP) during flu H1N1 pandemia based on hospital admission data.Materials: 84 patients (43 survivors and 41 non-survivors) admitted with VBCAP in hospitals of Bashkortostan region between November and December 2009 were included in the retrospective study. The endpoint was defined as hospital mortality.Methods and results: Initially 16 demography, history, functional and laboratory variables were obtained from hospital admission records. In the univariate ROC analysis, 5 variables were correlated with poor outcome of VBCAP.View this table:Univariate ROC-analysis resultsCutoffs were used to transfer continuous variables to dichotomous ones. Multivariate stepwise logistic regression analysis identified SpO2\% and white blood cell count as independent predictive factors at p\<0.05.Logistic regression equation:logit P = 3,49{\texttimes}{\textquotedblleft}SpO2\<90\%{\textquotedblright}+ 2,24{\texttimes}{\textquotedblleft}WBC\<6,9{\texttimes}109/l{\textquotedblright} {\textendash} 1,76, where P- poor outcome probability. Correct classification rate was 82,8\%.Conclusion: Acute respiratory failure and diminished immune response are the most powerful independent prognostic factors of poor outcome of viral-bacterial pneumonia during flu H1N1 pandemia.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/38/Suppl_55/p496}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }