PT  - JOURNAL ARTICLE
AU  - Dragana Jovanovic
AU  - Ruza Stevic
AU  - Spasoje Popevic
AU  - Marta Velinovic
AU  - Natalija Samardzic
AU  - Dragana Maric
TI  - Potential role of antidepressants as part of anticancer therapy
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p2767
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p2767.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p2767.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Antidepressants are widely used as part of adjuvant analgesic therapy. Since in vitro studies show that antidepressants have potent anticancer properties, it raised the possibility of a potential role as a part of anticancer therapy.Aim: To estimate possible favorable effect of Mianserin (M) in lung cancer patients: (1) potential influence on survival due to anticancer properties, (2) improvement of patients psychological pattern and health-related quality of life (HRQoL).Methods: Two groups of advanced NSCLC patiens were included:52pts treated with CT with or without M and 60pts treated with BSC with or without M. Differences in response rates (only for CT treated group), in overall survival (OS) and HRQoL (based on EORTC QLQ-30 and QLQ-LC 13) within (sub)groups were evaluated.Results: The RR difference within the CT subgroups treated with or without M, was not statistically significant: 8/24 (33.33%) vs 6/28 (21.43%). There was significant difference in median OS with 95% CI for the different treatment subgroups (only BSC, BSC plus M, only CT and CT plus M), respectively: 6 (5-6), 7 (6-8), 8 (7-10) and 10.5 (10-13) months (p=1.89*10-15). Pts receiving M (and CT or BSC) had significantly better OS (p=0,0012). CT treated pts receiving M had significantly better survival comparing to those not receiving M (p=0.0015). BSC treated pts receiving M had also significantly better survival than those without M (p=0.003). M treated pts subgroups had significantly higher scores of QLQ-C30 and LC13 i.e. better HRQoL as well.Conclusion: Benefit of antidepressants as part of anticancer therapy noted should be further investigated in larger patients population studies with different antidepressant drugs.