RT Journal Article
SR Electronic
T1 Exercise training improves exercise capacity and quality of life in people with dust-related pleural and interstitial respiratory diseases: A randomised controlled trial
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1457
VO 38
IS Suppl 55
A1 Marita Dale
A1 Zoe McKeough
A1 Phillip Munoz
A1 Peter Corte
A1 Peter Bye
A1 Jennifer Alison
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/1457.abstract
AB The use of exercise training as a treatment option for people with dust-related pleural and interstitial respiratory diseases has not been evaluated. A randomised controlled trial was conducted to determine whether exercise training improved exercise capacity and quality of life in people with dust-related respiratory diseases compared to usual care. The inclusion criterion was a medical diagnosis of a dust-related respiratory disease including asbestosis, silicosis and asbestos related diffuse pleural thickening. Participants were randomised to exercise training (eight weeks, three times per week) or usual care (control). Exercise capacity (six-minute walk test and endurance cycle test) and quality of life (St George's Respiratory Questionnaire) were measured at baseline and at eight weeks by a blinded assessor. Thirty-six of 37 participants completed the study (mean (SD) age 71 (7) years, FVC 86 (20)% predicted, DLCO 56 (14)% predicted). Compared to usual care, exercise training significantly increased six-minute walk distance (mean difference 50 metres, 95% CI 29 to 71), endurance cycle time (mean difference 225 seconds, 95% CI 92 to 359) and significantly improved the St George's Respiratory Questionnaire Total score (mean difference -7, 95% CI -12 to -1). Improvements in exercise capacity and quality of life reached the minimum clinically important difference established for chronic obstructive pulmonary disease. Exercise training is an effective treatment option for improving exercise capacity and quality of life in people with dust-related pleural and interstitial respiratory diseases.