TY - JOUR T1 - Asthma severity and duration influence to fetoplacental circulation JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p4918 AU - Olga Lavrova AU - Maria Petrova AU - Elena Shapovalova Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p4918.abstract N2 - Hemodynamic of fetoplacental circulation in Asthmatic patients is not studied enough yet. Modern data on asthma severity duration and its control influence to fetoplacental circulation are still lack and controversial.The goal of our study was investigation of fetoplacental circulation with ultrasonic dopplerography. Pregnants with different asthma severity and treatment were studied at 34 week of gestation.Materials & methods: 73 Asthmatic pregnants were studied (5 - severe persistent, 18 - moderate persistent, 22 - mild persistent & 28 - mild intermittent). 64 females without lung pathology were studied also as a control group (K). ICS were administered to 55 patients. Among them 17 rejected ICS use and were administered SABA with other medications instead. Systolo-diastolic ratio (SD) in uterine (UA), umbilical (UmA) and fetus medial cerebral (ACM) arteries was measured.Results: SD was increased in UA and ACM within asthmatics, but with no significantly differences. In moderate persistent asthma SD was significantly higher in UA (2,51±0,29) in comparison with mild persistent (1,91±0,18) and with K (1,95±0,13) (p<0,05). In pregnants, who undergone asthma relapse during the first trimester SD in UA (2,69±0,12) differed (p<0,05) in comparison with K. Reliable UA and ACM SD level differences were accepted in patients with moderate persistent asthma, who were administered ICS to ICS free patients (1,91±0,15 to 2,82±0,59) and (4,39±0,43 to 5,98±0,68) respectively (p<0,05).Conclusions: Relapse of Asthma in the first trimester of pregnancy, severity of Asthma and absence of basic therapy influence level of the blood flow in UA. Absence of basic therapy leads to increase of blood pressure in ACM of fetus. ER -