RT Journal Article
SR Electronic
T1 Maternal asthma phenotypes and children's allergy status
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p1137
VO 38
IS Suppl 55
A1 Maria Vakharlovskaya
A1 Olga Lavrova
A1 Maria Petrova
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p1137.abstract
AB Background: Asthma is a complex heterogeneous disease comprising a number of discrete phenotypes. Allergy status in children tends to differ according to asthmatic phenotype of parents, particularly mothers. Mother's asthmatic phenotype stipulates for differences in structure and time of allergy onset in children.Purpose: To study the influence of maternal asthma phenotype on children's allergy status.Methods: We evaluated the allergy status in children from birth to 7 years of age born from 117 asthmatic mothers with regard to their asthma phenotypes; 88 (75.2%) mothers had early onset asthma phenotype (defined as asthma developing before 16 years of age), 29 (24.8%) – late onset phenotype.Results: The prevalence of allergic asthma and other allergic forms (allergic rhinitis and atopic dermatitis) in children by 7 years of life differed (p<0.001, binomial test) depending on the onset asthma phenotypes of mothers. Children born from mothers with early onset asthma phenotypes will be at higher asthma and others allergic forms risk (OR=3,04 [CI: 1.013-9.132]).Conclusions: Maternal asthma phenotype influences the onset and structure of allergy in children. Understanding of underlying asthma genesis is needed for protective measures and prognosis of the diseases in children.