RT Journal Article
SR Electronic
T1 Determinants of lung function and bronchodilator response in 4-year-old children
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p1508
VO 38
IS Suppl 55
A1 Sandra Dom
A1 Ellie Oostveen
A1 Jos Droste
A1 Margo Hagendorens
A1 Joost Weyler
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p1508.abstract
AB Objectives: The aim of this study was to investigate which early life factors are associated with baseline lung function and the change after bronchodilation in 4-year-old children.Methods: Environmental and health information on children involved in a Belgian prospective birth cohort (PIPO) were collected from birth on using bi-annual questionnaires. At 1 and 4 years of age, a blood sample was analysed for specific IgE. At 4 years of age, baseline and post-bronchodilator respiratory resistance at 6 Hz (R6) was obtained with the forced oscillation technique. Potential determinants were selected based on literature and univariate analyses. Response variables were transformed to allow for the normal distribution assumption. Model reduction on the initial multiple linear regression models was performed by stepwise backward elimination based on the 95% confidence level.Results: Baseline and post-bronchodilator R6 data were obtained in 535 and 501 children, respectively. Results are regression coefficient B with standard error. Current height (-0.017 (0.004)) and weight of the child (0.015 (0.008)), maternal asthma (0.108 (0.047)), lower respiratory tract infections (0.064 (0.025)) and atopy against cat at the age of 1 year (0.236 (0.085)) were significant determinants of the baseline R6 value. Interestingly, other determinants were observed for ΔR6, namely parental educational level (-0.080 (0.041)), pre-and postnatal smoke exposure (0.158 (0.067)), lower respiratory tracts infections (0.075 (0.027)) and atopy against dog at 1 year of age (0.311 (0.124)).Conclusion: In 4-year-old children different determinants for the baseline respiratory resistance and the bronchodilator response were observed.