RT Journal Article
SR Electronic
T1 Effect of urbanisation on the relationship between total serum IgE and asthma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1074
OP 1081
DO 10.1183/09031936.00025512
VO 41
IS 5
A1 William Checkley
A1 Colin L. Robinson
A1 Lauren M. Baumann
A1 Karina Romero
A1 Juan M. Combe
A1 Robert H. Gilman
A1 Robert A. Wise
A1 Robert G. Hamilton
A1 Guillermo Gonzalvez
A1 Vitaliano Cama
A1 Nadia N. Hansel
A1 the PURA study investigators
YR 2013
UL http://erj.ersjournals.com/content/41/5/1074.abstract
AB It is unclear if the relationship of total serum IgE with asthma varies with degree of urbanisation. We hypothesised that the relationship of total serum IgE to asthma is more pronounced in an urban versus a rural environment. We enrolled 1441 children aged 13–15 years in a peri-urban shanty town in Lima, Peru (n=725) and 23 villages in rural Tumbes, Peru (n=716). We asked participants about asthma and allergy symptoms, environmental exposures and sociodemographics; and performed spirometry, and exhaled nitric oxide and allergy skin testing. We obtained blood for total serum IgE in 1143 (79%) participants. Geometric means for total serum IgE were higher in Lima versus Tumbes (262 versus 192 kU·L−1; p<0.001). The odds of asthma increased by factors of 1.6 (95% CI 1.3–2.0) versus 1.4 (95% CI 0.9–2.1) per log unit increase in total serum IgE in Lima versus Tumbes, respectively. Atopy was an effect modifier of the relationship of total serum IgE on asthma. Among atopics and non-atopics, the odds of asthma increased by a factor of 2.0 (95% CI 1.5–2.7) and 1.0 (95% CI 0.7–1.4) per log unit increase in total serum IgE, respectively. Total serum IgE was associated with atopic asthma but not with non-atopic asthma. Urbanisation did not appear to be an effect modifier of this relationship.