RT Journal Article
SR Electronic
T1 Circulating DBP level and prognosis in operated lung cancer: an exploration of pathophysiology
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 410
OP 416
DO 10.1183/09031936.00002912
VO 41
IS 2
A1 Alice M. Turner
A1 Laura McGowan
A1 Alan Millen
A1 Pala Rajesh
A1 Craig Webster
A1 Gerald Langman
A1 Gavin Rock
A1 Isao Tachibana
A1 Michael G. Tomlinson
A1 Fedor Berditchevski
A1 Babu Naidu
YR 2013
UL http://erj.ersjournals.com/content/41/2/410.abstract
AB Vitamin D stimulates transcription of antiangiogenic and apoptotic factors that may suppress tumours, while vitamin D binding protein (DBP) may be a biomarker in murine lung cancer models. We sought to ascertain whether the vitamin D axis is altered in lung cancer or influences prognosis. 148 lung cancer patients, 68 other intrathoracic cancer patients and 33 noncancer controls were studied for up to 5 yrs. Circulating DBP and vitamin D levels were compared between groups and their effect on survival assessed by Cox regression analysis. Expression of DBP and vitamin D receptor (VDR) was examined in lung cancer cell lines and in normal and tumour lung tissue by Western blot and immunohistochemistry. Low serum DBP levels predicted lung cancer-specific death (p=0.04), and DBP was poorly expressed in lung cancer cells on Western blot and immunohistochemistry. Vitamin D did not predict cancer survival and VDR expression was variable in tumours. Preservation of serum DBP is a significant independent factor associated with better cancer outcome in operated lung cancer patients. Given the established role of DBP in macrophage activation and clearance of abnormal cells, further study on its involvement in lung cancer is merited.