RT Journal Article
SR Electronic
T1 Nocturnal hypoxaemia and hypercapnia in children with neuromuscular disorders
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1206
OP 1212
DO 10.1183/09031936.00087511
VO 39
IS 5
A1 Chiara Bersanini
A1 Sonia Khirani
A1 Adriana Ramirez
A1 Frédéric Lofaso
A1 Guillaume Aubertin
A1 Nicole Beydon
A1 Michèle Mayer
A1 Kim Maincent
A1 Michèle Boulé
A1 Brigitte Fauroux
YR 2012
UL http://erj.ersjournals.com/content/39/5/1206.abstract
AB The aim of the study was to identify daytime predictors of nocturnal gas exchange anomalies in children with neuromuscular disease (NMD) and normal daytime gas exchange. Lung function tests, respiratory muscle evaluation and nocturnal gas exchange were obtained as part of routine evaluation. We included 52 consecutive children with Duchenne muscular dystrophy (n=20), spinal muscular atrophy (n=10) and other NMD (n=22). 20 patients had nocturnal hypoxaemia, defined as minimal arterial oxygen saturation measured by pulse oximetry (Sp,O2) <90% for ≥2% of night time, and 22 had nocturnal hypercapnia, defined as maximal transcutaneous carbon dioxide tension (Ptc,CO2) >50 mmHg for ≥2% of night time. Forced vital capacity and helium functional residual capacity correlated with minimal nocturnal Sp,O2 (p=0.009 and p=0.01, respectively). Daytime pH correlated negatively with maximal nocturnal Ptc,CO2 (p=0.005) and daytime arterial carbon dioxide tension (Pa,CO2) correlated with the percentage of time with a Ptc,CO2 >50 mmHg (p=0.02). Sniff nasal inspiratory pressure correlated with minimal nocturnal Sp,O2 (p=0.02). Daytime Pa,CO2 was a weak predictor of nocturnal hypercapnia (sensitivity 80%; specificity 57%). Daytime lung function and respiratory muscle parameters correlate poorly with nocturnal hypoxaemia and hypercapnia in children with NMD and normal daytime gas exchange, which necessitates more systematic sleep studies in these children.