TY - JOUR T1 - Endothelin-1 and interleukin-8 in high altitude pulmonary oedema JF - European Respiratory Journal JO - Eur Respir J SP - 1947 LP - 1949 DO - 10.1183/09031936.96.09091947 VL - 9 IS - 9 AU - Y Droma AU - T Hayano AU - Y Takabayashi AU - T Koizumi AU - K Kubo AU - T Kobayashi AU - M Sekiguchi Y1 - 1996/09/01 UR - http://erj.ersjournals.com/content/9/9/1947.abstract N2 - We present a case of high altitude pulmonary oedema (HAPE) with pulmonary hypertension and polymorphonuclear leucocyte (PMN) accumulation in bronchoalveolar lavage fluid (BALF), which occurred in a 21 year old man. Plasma endothelin-1 (ET-1) and interleukin-8 (IL-8) concentration in BALF were elevated on admission, and returned to normal level at recovery, when the pulmonary artery pressure and the PMN counts in BALF were normal. In addition, E-selectin and intercellular adhesion molecule-1 (ICAM-1) in BALF were also slightly increased on admission. These findings suggest that endothelin-1 is a vasoconstrictor which contributes to the pulmonary hypertension in high altitude pulmonary oedema, and that some of the inflammatory mediators play an important role in chemotaxis and accumulation of polymorphonuclear leucocytes in the development of high altitude pulmonary oedema. ER -