TY - JOUR T1 - Lung deposition of budesonide from Turbuhaler is twice that from a pressurized metered-dose inhaler P-MDI JF - European Respiratory Journal JO - Eur Respir J SP - 1839 LP - 1844 DO - 10.1183/09031936.94.07101839 VL - 7 IS - 10 AU - L Thorsson AU - S Edsbacker AU - TB Conradson Y1 - 1994/10/01 UR - http://erj.ersjournals.com/content/7/10/1839.abstract N2 - The pulmonary and systemic availability of budesonide after inhalation from a dry powder inhaler, Turbuhaler, and from a pressurized metered-dose inhaler (P-MDI) were compared in healthy volunteers. Two different methods were used to assess pulmonary availability: 1) calculated from the systemic availability corrected for an oral availability of 13% (n = 24); and 2) after blocking of gastrointestinal absorption by administration of a charcoal suspension (n = 13). An intravenous infusion of budesonide was used as a reference. The systemic availability of budesonide, calculated as a geometric mean and expressed as percentage of the metered dose, was 38% for Turbuhaler and 26% for P-MDI. The pulmonary availability, calculated using the first method, was 32% and 15% for Turbuhaler and P-MDI, respectively; and, using the second method, 32% and 18%, respectively. The results of the present study indicate that administration of budesonide via Turbuhaler gives rise to a lung deposition which is approximately twice that of a P-MDI, with less variability, but that systemic availability is only increased by approximately 50%. Thus, the present data suggest that by administrating budesonide via Turbuhaler, instead of a P-MDI, the same degree of asthma control can be achieved with a lower dose, which, in turn, reduces the risk of undesired systemic effects. ER -