RT Journal Article
SR Electronic
T1 The effect of ambient air pollution on exhaled nitric oxide in the Children's Health Study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1029
OP 1036
DO 10.1183/09031936.00081410
VO 37
IS 5
A1 K. Berhane
A1 Y. Zhang
A1 W.S. Linn
A1 E.B. Rappaport
A1 T.M. Bastain
A1 M.T. Salam
A1 T. Islam
A1 F. Lurmann
A1 F.D. Gilliland
YR 2011
UL http://erj.ersjournals.com/content/37/5/1029.abstract
AB We assessed the effect of daily variations in ambient air pollutants on exhaled nitric oxide fraction (FeNO) using data from a cohort of school children with large differences in air pollutant exposures from the Children's Health Study. Based on a cohort of 2,240 school children from 13 Southern Californian communities, cumulative lagged average regression models were fitted to determine the association between FeNO and ambient air pollution levels from central site monitors with lags of up to 30 days prior to FeNO testing. Daily 24-h cumulative lagged averages of particles with a 50% cut-off aerodynamic diameter of 2.5 µm (PM2.5; over 1–8 days) and particles with a 50% cut-off aerodynamic diameter of 10 µm (PM10; over 1–7 days), as well as 10:00–18:00 h cumulative lagged average of O3 (over 1–23 days) were significantly associated with 17.42% (p<0.01), 9.25% (p<0.05) and 14.25% (p<0.01) higher FeNO levels over the interquartile range of 7.5 μg·m−3, 12.97 μg·m−3 and 15.42 ppb, respectively. The effects of PM2.5, PM10 and O3 were higher in the warm season. The particulate matter effects were robust to adjustments for effects of O3 and temperature and did not vary by asthma or allergy status. In summary, short-term increases in PM2.5, PM10 and O3 were associated with airway inflammation independent of asthma and allergy status, with PM10 effects significantly higher in the warm season.