TY - JOUR T1 - The effect of ambient air pollution on exhaled nitric oxide in the Children's Health Study JF - European Respiratory Journal JO - Eur Respir J SP - 1029 LP - 1036 DO - 10.1183/09031936.00081410 VL - 37 IS - 5 AU - K. Berhane AU - Y. Zhang AU - W.S. Linn AU - E.B. Rappaport AU - T.M. Bastain AU - M.T. Salam AU - T. Islam AU - F. Lurmann AU - F.D. Gilliland Y1 - 2011/05/01 UR - http://erj.ersjournals.com/content/37/5/1029.abstract N2 - We assessed the effect of daily variations in ambient air pollutants on exhaled nitric oxide fraction (FeNO) using data from a cohort of school children with large differences in air pollutant exposures from the Children's Health Study. Based on a cohort of 2,240 school children from 13 Southern Californian communities, cumulative lagged average regression models were fitted to determine the association between FeNO and ambient air pollution levels from central site monitors with lags of up to 30 days prior to FeNO testing. Daily 24-h cumulative lagged averages of particles with a 50% cut-off aerodynamic diameter of 2.5 µm (PM2.5; over 1–8 days) and particles with a 50% cut-off aerodynamic diameter of 10 µm (PM10; over 1–7 days), as well as 10:00–18:00 h cumulative lagged average of O3 (over 1–23 days) were significantly associated with 17.42% (p<0.01), 9.25% (p<0.05) and 14.25% (p<0.01) higher FeNO levels over the interquartile range of 7.5 μg·m−3, 12.97 μg·m−3 and 15.42 ppb, respectively. The effects of PM2.5, PM10 and O3 were higher in the warm season. The particulate matter effects were robust to adjustments for effects of O3 and temperature and did not vary by asthma or allergy status. In summary, short-term increases in PM2.5, PM10 and O3 were associated with airway inflammation independent of asthma and allergy status, with PM10 effects significantly higher in the warm season. ER -