RT Journal Article
SR Electronic
T1 17q21 variants modify the association between early respiratory infections and asthma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 57
OP 64
DO 10.1183/09031936.00154509
VO 36
IS 1
A1 L.A.M. Smit
A1 E. Bouzigon
A1 I. Pin
A1 V. Siroux
A1 F. Monier
A1 H. Aschard
A1 J. Bousquet
A1 F. Gormand
A1 J. Just
A1 N. Le Moual
A1 R. Nadif
A1 P. Scheinmann
A1 D. Vervloet
A1 M. Lathrop
A1 F. Demenais
A1 F. Kauffmann
YR 2010
UL http://erj.ersjournals.com/content/36/1/57.abstract
AB Single nucleotide polymorphisms (SNPs) at chromosome 17q21 confer an increased risk of early-onset asthma. The objective was to study whether 17q21 SNPs modify associations between early respiratory infections and asthma. Association analysis was conducted in 499 children (268 with asthma, median age 11 yrs) from the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). The 12-yr follow-up data were used to assess persistent or remittent asthma in young adulthood. Respiratory infection before 2 yrs of age was assessed retrospectively. For the 12 17q21 SNPs studied, the odds ratios (OR) for association between infection and early-onset asthma (age at onset ≤4 yrs) were higher in carriers of risk genotypes (OR 3.42–6.36) than in noncarriers (OR 1.84–2.44; p-value for interaction 0.02–0.04 for five SNPs). Risk genotypes also increased the association between infection and childhood asthma that remits in adulthood (OR 4.84–7.16 in carriers and 1.74–2.25 in noncarriers; p-value for interaction 0.008–0.05 for 10 SNPs). In children with 17q21 risk genotypes and early-life environmental tobacco smoke (ETS) exposure, associations between infection and asthma were further enhanced. 17q21 genetic variants and early ETS exposure enhance the association between early respiratory infections and early-onset asthma and childhood asthma that remits in adulthood.