RT Journal Article
SR Electronic
T1 Mortality in bronchiectasis: a long-term study assessing the factors influencing survival
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 843
OP 849
DO 10.1183/09031936.00003709
VO 34
IS 4
A1 M. R. Loebinger
A1 A. U. Wells
A1 D. M. Hansell
A1 N. Chinyanganya
A1 A. Devaraj
A1 M. Meister
A1 R. Wilson
YR 2009
UL http://erj.ersjournals.com/content/34/4/843.abstract
AB There is little literature about the mortality associated with bronchiectasis. The aim of the present study was to investigate factors affecting mortality in patients with bronchiectasis. In total, 91 patients were examined for aetiology, pulmonary function tests, high-resolution computed tomography, sputum microbiology and quality of life scores and were then followed over 13 yrs. Overall, 29.7% of the patients died. On multivariate analysis, age, St George’s Respiratory Questionnaire activity score, Pseudomonas aeruginosa infection, total lung capacity (TLC), residual volume/TLC and the transfer factor coefficient were all independently associated with mortality. In patients with moderate to severe bronchiectasis, mortality is associated with a degree of restrictive and obstructive disease, poor gas transfer and chronic pseudomonas infection. These features should guide future research into disease progression, and identify those patients needing intensive treatment.