RT Journal Article
SR Electronic
T1 Clinical characteristics and prognostic factors of pulmonary MALT lymphoma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1408
OP 1416
DO 10.1183/09031936.00039309
VO 34
IS 6
A1 R. Borie
A1 M. Wislez
A1 G. Thabut
A1 M. Antoine
A1 A. Rabbat
A1 L-J. Couderc
A1 I. Monnet
A1 H. Nunes
A1 F-X. Blanc
A1 H. Mal
A1 A. Bergeron
A1 D. Dusser
A1 D. Israël-Biet
A1 B. Crestani
A1 J. Cadranel
YR 2009
UL http://erj.ersjournals.com/content/34/6/1408.abstract
AB Mucosa-associated lymphoid tissue-derived (MALT) lymphoma, a low grade B-cell extranodal lymphoma, is the most frequent subset of primary pulmonary lymphoma. Our objective was to evaluate the initial extent of disease and to analyse the characteristics and long-term outcome of these patients. All chest and pathological departments of teaching hospitals in Paris were contacted in order to identify patients with a histological diagnosis of primary pulmonary lymphoma of the MALT subtype. 63 cases were identified. The median age was 60 yrs. 36% of cases had no symptoms at diagnosis. 46% of patients had at least one extrapulmonary location of lymphoma. The estimated 5- and 10-yr overall survival rates were 90% and 72%, respectively. Only two of the nine observed deaths were related to lymphoma. Age and performance status were the only two adverse prognostic factors for survival. Extrapulmonary location of lymphoma was not a prognostic factor for overall survival or for progression-free survival. Treatment with cyclophosphamide or anthracyclin was associated with shorter progression-free survival, when compared with chlorambucil. The survival data confirm the indolent nature of pulmonary MALT lymphoma. Better progression-free survival was observed with chlorambucil when compared with cyclophosphamide or anthracyclin.