TY - JOUR T1 - Local immunodiagnosis of pulmonary TB: ELISPOT or flow cytometry, PPD or ESAT-6? JF - European Respiratory Journal JO - Eur Respir J SP - 531 LP - 532 DO - 10.1183/09031936.00043908 VL - 32 IS - 2 AU - S. Barry AU - M. Lipman AU - R. Breen AU - G. Janossy Y1 - 2008/08/01 UR - http://erj.ersjournals.com/content/32/2/531.abstract N2 - To the Editors: Immunodiagnosis is a significant addition to the diagnostic armamentarium in tuberculosis (TB) infection and disease. For some time it has been known that cells secreting type-1 cytokines, such as interferon (IFN)-γ and tumour necrosis factor-α, selectively accumulate in the lung in higher frequencies than in the blood 1, as would be expected in a disease dominated by pulmonary pathology. In a recent issue of the European Respiratory Journal, Jafari et al. 2 detailed the TB-specific response in bronchoalveolar lavage (BAL) and blood from 12 patients with culture-positive but smear negative disease. Jafari et al. 2 used a … ER -