PT  - JOURNAL ARTICLE
AU  - A. M. B. Menezes
AU  - P. C. Hallal
AU  - R. Perez-Padilla
AU  - J. R. B. Jardim
AU  - A. Muiño
AU  - M. V. Lopez
AU  - G. Valdivia
AU  - M. Montes de Oca
AU  - C. Talamo
AU  - J. Pertuze
AU  - C. G. Victora
ED  - ,
TI  - Tuberculosis and airflow obstruction: evidence from the PLATINO study in Latin America
AID  - 10.1183/09031936.00083507
DP  - 2007 Dec 01
TA  - European Respiratory Journal
PG  - 1180--1185
VI  - 30
IP  - 6
4099  - http://erj.ersjournals.com/content/30/6/1180.short
4100  - http://erj.ersjournals.com/content/30/6/1180.full
SO  - Eur Respir J2007 Dec 01; 30
AB  - The aim of the present study was to evaluate the association between history of tuberculosis and airflow obstruction. A population-based, multicentre study was carried out and included 5,571 subjects aged ≥40 yrs living in one of five Latin American metropolitan areas: Sao Paulo (Brazil); Montevideo (Uruguay); Mexico City (Mexico); Santiago (Chile); and Caracas (Venezuela). Subjects performed pre- and post-bronchodilator spirometry and were asked whether they had ever been diagnosed with tuberculosis by a physician. The overall prevalence of airflow obstruction (forced expiratory volume in one second/forced vital capacity post-bronchodilator <0.7) was 30.7% among those with a history of tuberculosis, compared with 13.9% among those without a history. Males with a medical history of tuberculosis were 4.1 times more likely to present airflow obstruction than those without such a diagnosis. This remained unchanged after adjustment for confounding by age, sex, schooling, ethnicity, smoking, exposure to dust and smoke, respiratory morbidity in childhood and current morbidity. Among females, the unadjusted and adjusted odds ratios were 2.3 and 1.7, respectively. In conclusion, history of tuberculosis is associated with airflow obstruction in Latin American middle-aged and older adults.