RT Journal Article
SR Electronic
T1 Exposure–response analysis of allergy and respiratory symptoms in endotoxin-exposed adults
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1241
OP 1248
DO 10.1183/09031936.00090607
VO 31
IS 6
A1 L. A. M. Smit
A1 D. Heederik
A1 G. Doekes
A1 C. Blom
A1 I. van Zweden
A1 I. M. Wouters
YR 2008
UL http://erj.ersjournals.com/content/31/6/1241.abstract
AB The objective of the present study was to investigate exposure–response relationships between current endotoxin exposure and allergic and respiratory symptoms in adults, taking into account farming exposures during childhood. A cross-sectional study was conducted among 877 Dutch farmers and agricultural industry workers in 2006. Based on 249 full-shift personal airborne endotoxin samples, a job-exposure matrix was constructed to assign endotoxin exposure levels to all participants. Associations between endotoxin exposure and questionnaire data on symptoms were studied by multiple logistic regression. Adjusted odds ratios (OR) for an interquartile range increase in endotoxin level were elevated for respiratory symptoms such as wheezing (OR 1.41 (95% confidence interval 1.16–1.72)), wheezing with shortness of breath (1.50 (1.18–1.90)) and daily cough (1.29 (1.03–1.62)). In contrast, endotoxin was strongly associated with a decreased prevalence of hay fever (0.62 (0.49–0.78)). Workers who had grown up on a farm had a lower prevalence of hay fever, but no evidence was found of effect modification by farm childhood. In conclusion, occupational endotoxin exposure in adulthood is associated with an increased risk of asthma-like symptoms but a reduced prevalence of hay fever.