RT Journal Article
SR Electronic
T1 The association between serum osmolality and lung function among adults
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 98
OP 104
DO 10.1183/09031936.00144207
VO 32
IS 1
A1 Z. E. K. Pogson
A1 T. M. McKeever
A1 A. Fogarty
YR 2008
UL http://erj.ersjournals.com/content/32/1/98.abstract
AB The extensive pulmonary vasculature results in the lungs being intimately exposed to circulating blood. As increased serum osmolality may be associated with an increase in pro-inflammatory activity, this has the potential to result in damage to the lungs and reduced lung function. The objective of the present study was to test the hypothesis that increased serum osmolality is associated with a lower forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). The present study was a cross-sectional study of 10,602 participants in the Third National Health and Nutrition Examination Survey aged ≥17 yrs for whom there were adequate data on all outcomes and exposures. After adjustment for age, smoking and other confounding factors, increased serum osmolality was inversely associated with both FEV1 and FVC. An increase of 1 sd in serum osmolality was associated with a decrease in both FEV1 of 19.8 mL and FVC of 35.3 mL. The constituent assays demonstrated a complex relationship with both FEV1 and FVC. Increased serum osmolality was associated with decreased forced expiratory volume in one second and forced vital capacity. If causal, this may have implications for the understanding of the processes that are involved in the pathophysiology of decline in lung function.