TY - JOUR T1 - T-cell co-stimulatory molecules: their role in allergic immune reactions JF - European Respiratory Journal JO - Eur Respir J SP - 1246 LP - 1255 DO - 10.1183/09031936.00094306 VL - 29 IS - 6 AU - T. Kallinich AU - K. C. Beier AU - U. Wahn AU - P. Stock AU - E. Hamelmann Y1 - 2007/06/01 UR - http://erj.ersjournals.com/content/29/6/1246.abstract N2 - The development of allergic diseases, such as allergic asthma, depends upon the initiation and maintenance of T-helper cell type-2-skewed allergen-specific immune reactions. Although it is clear that susceptibility to this process is under genetic and environmental control, the fine-tuning and regulation of the type-2 T-helper cell immune response is not yet fully understood. In this second article in the present series, current understanding regarding the involvement of T-cells and antigen-presenting cells is summarised, with emphasis on the interaction between these two types of immune regulatory cells by means of co-stimulatory molecules. MINI-SERIES “T-CELL CO-STIMULATORY MOLECULES” Edited by M. Belvisi and K.F. Rabe Number 2 in this Series ER -