RT Journal Article
SR Electronic
T1 Severe airflow obstruction and eosinophilic lung disease after Stevens–Johnson syndrome
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1276
OP 1279
DO 10.1183/09031936.00036006
VO 28
IS 6
A1 A. P. Shah
A1 H. Xu
A1 P. J. Sime
A1 D. R. Trawick
YR 2006
UL http://erj.ersjournals.com/content/28/6/1276.abstract
AB Respiratory involvement is a frequent complication of Stevens–Johnson syndrome (SJS). However, there are very few convincing reports of persistent pulmonary sequelae, as demonstrated by spirometry, radiology and pathology. The current study presents a case of a 13-yr-old female with T-cell acute lymphocytic leukaemia who developed persistent, severe, obstructive lung disease following an episode of SJS. A lung biopsy demonstrated bronchiolar submucosal fibrosis consistent with constrictive bronchiolitis, as well as eosinophilic micro-abscesses, which, to the current authors’ knowledge, has not been previously described. The present study illustrates specific histopathological features that highlight a possible association between Stevens–Johnson syndrome, constrictive bronchiolitis and eosinophilic micro-abscesses. The eosinophils may be associated with permanent mucosal damage, as seen in the present case, by releasing mediators that have a pro-fibrogenetic role. However, further investigation is warranted.