TY - JOUR T1 - Should patients with lymphangioleiomyomatosis undergo screening for meningioma? JF - European Respiratory Journal JO - Eur Respir J SP - 888 LP - 889 DO - 10.1183/09031936.04.10079704 VL - 24 IS - 5 AU - V. Cottin AU - S. Vukusic AU - E. Jouanneau AU - R. Lazor AU - J-F. Cordier Y1 - 2004/11/01 UR - http://erj.ersjournals.com/content/24/5/888.abstract N2 - To the Editors: Pulmonary lymphangioleiomyomatosis (LAM) may be sporadic or associated with tuberous sclerosis complex (TSC). Recently, routine screening for brain abnormalities associated with TSC demonstrated the presence of meningioma in 3.2% of patients with LAM (with or without TSC), a prevalence exceeding that expected in the general population 1, thus suggesting that meningiomas may be associated with LAM or its treatment. Indeed, most patients diagnosed with meningioma (seven out of eight) had received hormone replacement therapy and/or progesterone. Hitherto reported cases of meningiomas associated with LAM were mostly asymptomatic 1, with ensuing controversy about the usefulness of systematic brain imaging in patients with LAM 2. We report the occurrence of symptomatic meningiomas requiring surgery in a patient who had received progesterone therapy for 17 yrs for pulmonary LAM. A female born … ER -