TY - JOUR T1 - Reversibility of pulmonary arterial hypertension in HIV/HHV8-associated Castleman's disease JF - European Respiratory Journal JO - Eur Respir J SP - 969 LP - 972 DO - 10.1183/09031936.05.00133904 VL - 26 IS - 5 AU - D. Montani AU - L. Achouh AU - A. G. Marcelin AU - J-P. Viard AU - O. Hermine AU - D. Canioni AU - O. Sitbon AU - G. Simonneau AU - M. Humbert Y1 - 2005/11/01 UR - http://erj.ersjournals.com/content/26/5/969.abstract N2 - The present study describes a case of pulmonary arterial hypertension (PAH) associated with multicentric Castleman's disease in a patient infected with HIV type 1 and human herpes virus 8. Therapy included highly active antiretroviral therapy, warfarin, diuretics, continuous i.v. epoprostenol and 12-monthly pulses of cyclophosphamide. The patient's condition improved dramatically with complete reversibility of PAH, allowing weaning of continuous i.v. epoprostenol therapy. After 5 yrs, both Castleman's disease and PAH have not relapsed. This supports the hypothesis that control of inflammation and retroviral replication may be of interest in the context of PAH, complicating the course of an inflammatory condition associated with viral infection. In conclusion, further studies should help in characterising the best candidates for anti-inflammatory treatment in the setting of pulmonary arterial hypertension. ER -