PT  - JOURNAL ARTICLE
AU  - E. Udry
AU  - F. Bailly
AU  - M. Dusmet
AU  - P. Schnyder
AU  - R. Lemoine
AU  - J.W. Fitting
TI  - Pulmonary toxicity with mefloquine
DP  - 2001 Nov 01
TA  - European Respiratory Journal
PG  - 890--892
VI  - 18
IP  - 5
4099  - http://erj.ersjournals.com/content/18/5/890.short
4100  - http://erj.ersjournals.com/content/18/5/890.full
SO  - Eur Respir J2001 Nov 01; 18
AB  - This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy. Extensive microbiological investigation remained negative and video-assisted thoracoscopic lung biopsy demonstrated diffuse alveolar damage. The evolution was favourable without treatment. This is the second report of acute lung injury and diffuse alveolar damage caused by mefloquine. Glucose-;6-;phosphate dehydrogenase deficiency was present in the former case and was thought to contribute to the lung injury. However, glucose-phosphate dehydrogenase was normal in the present case, suggesting that it is not a predisposing condition to the lung injury.