RT Journal Article
SR Electronic
T1 Treatment of asthma by the inhaled corticosteroid ciclesonide given either in the morning or evening
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1083
OP 1088
DO 10.1183/09031936.01.00099701
VO 17
IS 6
A1 D.S. Postma
A1 C. Sevette
A1 Y. Martinat
A1 N. Schlösser
A1 J. Aumann
A1 H. Kafé
YR 2001
UL http://erj.ersjournals.com/content/17/6/1083.abstract
AB The study addressed the question whether the novel inhaled prodrug corticosteroid ciclesonide is equally effective when inhaled in the morning compared to the evening.For this purpose a double-blind, randomized, parallel group study was initiated in which 209 asthmatic patients (forced expiratory volume in one second=50–90% predicted) inhaled either 200 µg ciclesonide in the morning or in the evening, for 8 weeks. Efficacy was assessed by means of spirometry as well as daily recordings of morning and evening peak expiratory flow (PEF), symptoms and use of rescue medication. The 24-h urinary cortisol excretion was measured to evaluate any effect on hypothalamic-pituitary-adrenol axis.Ciclesonide significantly improved asthma control. Morning and evening administration was shown to be equally effective for the different spirometry variables, evening PEF, symptoms, use of rescue medication and number of asthma exacerbations. Regarding morning PEF, the improvements after evening dosing were more prominent and equivalence of morning and evening administration could not be demonstrated. No relevant influence on cortisol excretion was found.Overall, the study indicates that ciclesonide can be given either in the morning or in the evening to meet the patients' preference and individual medical needs, although evening administration may lead to a more pronounced improvement in morning peak expiratory flow.The study was supported by Byk Gulden Pharmaceuticals.