RT Journal Article SR Electronic T1 Heart-lung interactions: applications in the critically ill JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 226 OP 237 DO 10.1183/09031936.97.10010226 VO 10 IS 1 A1 HE Fessler YR 1997 UL http://erj.ersjournals.com/content/10/1/226.abstract AB Since the circulatory and pulmonary systems are both driven by pressure and share space in the thorax, it is inevitable that they interact. These mechanical interactions, whilst relatively few in number, are protean in their manifestations. The circulatory system of the critically ill is often particularly susceptible to interference from respiration. Compensatory reserve is limited, ventilatory effort increased, and many critical care respiratory interventions place strain on the circulation, not seen in health. This review will examine the basic physiological mechanisms through which the pulmonary and circulatory systems interact. These mechanisms will then be applied to a variety of weaning, positive end-expiratory pressure (PEEP), and cardiopulmonary resuscitation techniques. It is hoped that this will provide the tools to understand clinical observations which would otherwise appear inexplicable.