PT  - JOURNAL ARTICLE
AU  - K.A.M. van den Bergh
AU  - M.L. Essink-Bot
AU  - G.J.J.M. Borsboom
AU  - E.T. Scholten
AU  - R.J. van Klaveren
AU  - H.J. de Koning
TI  - Long-term effects of lung cancer computed tomography screening on health-related quality of life: the NELSON trial
AID  - 10.1183/09031936.00123410
DP  - 2011 Jul 01
TA  - European Respiratory Journal
PG  - 154--161
VI  - 38
IP  - 1
4099  - http://erj.ersjournals.com/content/38/1/154.short
4100  - http://erj.ersjournals.com/content/38/1/154.full
SO  - Eur Respir J2011 Jul 01; 38
AB  - The long-term effects of lung cancer computed tomography (CT) screening on health-related quality of life (HRQoL) have not yet been investigated. In the Dutch–Belgian Randomised Lung Cancer Screening Trial (NELSON trial), 1,466 participants received questionnaires before randomisation (T0), 2 months after baseline screening (screen group only; T1) and at 2-yr follow-up (T2). HRQoL was measured as generic HRQoL (12-item short-form questionnaire and EuroQoL questionnaire), anxiety (Spielberger State-Trait Anxiety Inventory) and lung cancer-specific distress (impact of event scale (IES)). Repeated measures of ANOVA were used to analyse differences between the screen and control groups, and between indeterminate (requiring a follow-up CT) and negative screening result groups. At T0 and T2 there were no significant differences in HRQoL scores over time between the screen and control groups, or between the indeterminate or negative second-round screening result group. There was a temporary increase in IES scores after an indeterminate baseline result (T0: mean 4.0 (95% CI 2.8–5.3); T1: mean 7.8 (95% CI 6.5–9.0); T2: mean 4.5 (95% CI 3.3–5.8)). At 2-yr follow-up, the HRQoL of screened subjects was similar to that of control subjects, the unfavourable short-term effects of an indeterminate baseline screening result had resolved and an indeterminate result at the second screening round had no impact on HRQoL.