TY - JOUR T1 - A systematic review of clinical trial registration in major respiratory journals 2010–2018 JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01491-2018 VL - 52 IS - 6 SP - 1801491 AU - Nelli S.M. Suntila AU - Alexandria Smith AU - Yusuf Al-Dabbagh AU - James D. Chalmers Y1 - 2018/12/01 UR - http://erj.ersjournals.com/content/52/6/1801491.abstract N2 - The results of randomised clinical trials are regarded as the highest level of evidence for informing clinical guidelines and clinical practice [1, 2]. The robustness of conduct and reporting of the results of randomised clinical trials is therefore of primary importance. To improve the transparency and quality of reporting of clinical trials, the International Committee of Medical Journal Editors (ICMJE) endorsed a policy on mandatory registration of clinical trials, which came into effect in July 2005 [3]. The trial registration recommendations outlined by the ICMJE state that a trial must be registered in a publicly accessible registry, before the enrolment of the first study participants, in order to be considered for publication. This policy is designed to reduce publication bias, prevent selective reporting of desirable or non-reporting of undesirable results, and reduce research waste by making the research community aware of what questions are already being addressed by active trials.Retrospective trial registration remains common in respiratory clinical trials, and may be associated with reporting bias http://ow.ly/S7p230m5kqV ER -