TY - JOUR T1 - Physical activity as a moderator for obstructive sleep apnoea and cardiometabolic risk in the EPISONO study JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01972-2017 VL - 52 IS - 4 SP - 1701972 AU - Marcos Mônico-Neto AU - Hanna Karen Moreira Antunes AU - Ronaldo Vagner Thomatieli dos Santos AU - Vânia D'Almeida AU - Altay Alves Lino de Souza AU - Lia Rita Azeredo Bittencourt AU - Sergio Tufik Y1 - 2018/10/01 UR - http://erj.ersjournals.com/content/52/4/1701972.abstract N2 - Obstructive sleep apnoea (OSA) is positively associated with cardiometabolic diseases; however, high levels of physical activity could decrease the incidence of OSA and associated comorbidities.In this study we aimed to examine the incidence of OSA in relation to physical activity, and its role as a protective factor in individuals with OSA on the incidence of cardiometabolic diseases, in an 8–9-year follow-up study. We analysed data of 658 volunteers from the São Paulo Epidemiologic Sleep Study (EPISONO), a cohort study of individuals aged 20–80 years, collected through polysomnography, the International Physical Activity Questionnaire and an assessment of cardiometabolic profile.Active subjects had a lower risk of developing OSA compared with nonactive subjects (relative risk 0.877, 95% CI 0.296–0.855) and there was a reduced risk of developing type 2 diabetes mellitus in active/apnoeic subjects (relative risk 0.493, 95% CI 0.252–0.961) compared with nonactive subjects. Metabolic equivalent was negatively associated to cardiometabolic markers, such as C-reactive protein (exp(B)=0.720; p=0.001), interleukin-6 (exp(B)=0.991; p=0.03), insulin (exp(B)=0.982; p=0.03), triglycerides (exp(B)=0.997; p<0.001), homeostasis model assessment for insulin resistance (exp(B)≤0.946; p<0.024), quantitative insulin sensitivity check index (exp(B)=992.4; p<0.001) and mean arterial pressure (exp(B)=0.987; p=0.001).Physical activity was a protective factor against type 2 diabetes mellitus in apnoeic individuals; moreover, being active reduced the risk of developing OSA and was associated with a better cardiometabolic profile.Physical activity reduces OSA incidence and protects against cardiometabolic diseases http://ow.ly/NxLh30leRPC ER -