RT Journal Article SR Electronic T1 Challenges and perspectives in obstructive sleep apnoea JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1702616 DO 10.1183/13993003.02616-2017 VO 52 IS 3 A1 Winfried Randerath A1 Claudio L. Bassetti A1 Maria R. Bonsignore A1 Ramon Farre A1 Luigi Ferini-Strambi A1 Ludger Grote A1 Jan Hedner A1 Malcolm Kohler A1 Miguel-Angel Martinez-Garcia A1 Stefan Mihaicuta A1 Josep Montserrat A1 Jean-Louis Pepin A1 Dirk Pevernagie A1 Fabio Pizza A1 Olli Polo A1 Renata Riha A1 Silke Ryan A1 Johan Verbraecken A1 Walter T. McNicholas YR 2018 UL http://erj.ersjournals.com/content/52/3/1702616.abstract AB Obstructive sleep apnoea (OSA) is a major challenge for physicians and healthcare systems throughout the world. The high prevalence and the impact on daily life of OSA oblige clinicians to offer effective and acceptable treatment options. However, recent evidence has raised questions about the benefits of positive airway pressure therapy in ameliorating comorbidities.An international expert group considered the current state of knowledge based on the most relevant publications in the previous 5 years, discussed the current challenges in the field, and proposed topics for future research on epidemiology, phenotyping, underlying mechanisms, prognostic implications and optimal treatment of patients with OSA.The group concluded that a revision to the diagnostic criteria for OSA is required to include factors that reflect different clinical and pathophysiological phenotypes and relevant comorbidities (e.g. nondipping nocturnal blood pressure). Furthermore, current severity thresholds require revision to reflect factors such as the disparity in the apnoea–hypopnoea index (AHI) between polysomnography and sleep studies that do not include sleep stage measurements, in addition to the poor correlation between AHI and daytime symptoms such as sleepiness. Management decisions should be linked to the underlying phenotype and consider outcomes beyond AHI.Clinical and pathophysiological phenotyping and personalised diagnostic and therapeutic procedures remain challenges in obstructive sleep apnoea management http://ow.ly/OhNU30jOCr3