PT  - JOURNAL ARTICLE
AU  - Yuan Zhang
AU  - Rebecca L. Morgan
AU  - Pablo Alonso-Coello
AU  - Wojtek Wiercioch
AU  - Małgorzata M. Bała
AU  - Rafał R. Jaeschke
AU  - Krzysztof Styczeń
AU  - Hector Pardo-Hernandez
AU  - Anna Selva
AU  - Housne Ara Begum
AU  - Gian Paolo Morgano
AU  - Marcin Waligóra
AU  - Arnav Agarwal
AU  - Matthew Ventresca
AU  - Karolina Strzebońska
AU  - Mateusz T. Wasylewski
AU  - Lídia Blanco-Silvente
AU  - Janna-Lina Kerth
AU  - Mengxiao Wang
AU  - Yuqing Zhang
AU  - Saiprasad Narsingam
AU  - Yutong Fei
AU  - Gordon Guyatt
AU  - Holger J. Schünemann
TI  - A systematic review of how patients value COPD outcomes
AID  - 10.1183/13993003.00222-2018
DP  - 2018 Jul 01
TA  - European Respiratory Journal
PG  - 1800222
VI  - 52
IP  - 1
4099  - http://erj.ersjournals.com/content/52/1/1800222.short
4100  - http://erj.ersjournals.com/content/52/1/1800222.full
SO  - Eur Respir J2018 Jul 01; 52
AB  - Our objective was to summarise systematically all research evidence related to how patients value outcomes in chronic obstructive pulmonary disease (COPD).We conducted a systematic review (systematic review registration number CRD42015015206) by searching PubMed, Embase, PsycInfo and CINAHL, and included reports that assessed the relative importance of outcomes from COPD patients' perspective. Two authors independently determined the eligibility of studies, abstracted the eligible studies and assessed risk of bias. We narratively summarised eligible studies, meta-analysed utilities for individual outcomes and assessed the certainty of evidence using the Grading of Recommendations, Assessment, Development and Evaluations approach.We included 217 quantitative studies. Investigators most commonly used utility measurements of outcomes (n=136), discrete choice exercises (n=13), probability trade-off (n=4) and forced choice techniques (n=46). Patients rated adverse events as important but on average, less so than symptom relief. Exacerbation and hospitalisation due to exacerbation are the outcomes that COPD patients rate as most important. This systematic review provides a comprehensive registry of related studies.Systematic review of the importance placed by patients on COPD outcomes informs the trade-off between benefits and harms http://ow.ly/l5De30kgD9g