TY - JOUR T1 - Home spirometry in bronchiolitis obliterans after allogeneic haematopoietic cell transplant JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.02328-2017 VL - 52 IS - 1 SP - 1702328 AU - Clémence Loiseau AU - François Lemonnier AU - Odile Randrianarivelo AU - Raphael Itzykson AU - Stéphanie Nguyen AU - Marie Hélène Becquemin AU - Colas Tcherakian AU - Madalina Uzunov AU - Emilie Catherinot AU - Elisabeth Rivaud AU - Hélène Salvator AU - Philippe Devillier AU - Laurent Sutton AU - Jean-Paul Vernant AU - Louis Jean Couderc AU - Nathalie Dhédin Y1 - 2018/07/01 UR - http://erj.ersjournals.com/content/52/1/1702328.abstract N2 - Bronchiolitis obliterans syndrome (BOS) is a well-characterised late-onset noninfectious pulmonary complication of allogeneic haematopoietic stem cell transplantation (HSCT), occurring in 2% to 26% of recipients [1]. It is considered to be a pulmonary manifestation of graft versus host disease (GVHD) [2] and is associated with a mortality rate varying from 14% to 100% in historical series [3, 4]. Although immunosuppressive drugs are modestly effective, early diagnosis and treatment could improve its outcome [5]. After lung transplantation, home spirometry monitoring of pulmonary function allows early detection of BOS [6]; it is associated with a better response to steroids [7] and consequently is considered as a standard of care [8]. Our group was the first to report the use of home spirometry in 37 HSCT recipients [9]. More recently, Cheng et al. [10] showed a good correlation between home spirometry and classical laboratory spirometry in this population. We present here the incidence and long-term outcome of BOS occurring after HSCT in an extended cohort of 110 patients monitored with home spirometry.Long-term outcome of patients with BOS after HSCT with home spirometry is encouraging despite suboptimal adherence http://ow.ly/mKfM30jDknzWe thank LVL Medical Company for technical assistance with home spirometry monitoring devices and Polly Gobin for English language revision. ER -