RT Journal Article
SR Electronic
T1 Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomisation analysis of the HUNT study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1800329
DO 10.1183/13993003.00329-2018
VO 51
IS 6
A1 Yi-Qian Sun
A1 Ben M. Brumpton
A1 Carolina Bonilla
A1 Sarah J. Lewis
A1 Stephen Burgess
A1 Frank Skorpen
A1 Yue Chen
A1 Tom I.L. Nilsen
A1 Pål Richard Romundstad
A1 Xiao-Mei Mai
YR 2018
UL http://erj.ersjournals.com/content/51/6/1800329.abstract
AB We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D (25(OH)D) levels and incidence of lung cancer overall and histologic types.We performed a Mendelian randomisation analysis using a prospective cohort study in Norway, including 54 580 individuals and 676 incident lung cancer cases. A 25(OH)D allele score was generated based on the vitamin D-increasing alleles rs2282679, rs12785878 and rs10741657. Hazard ratios with 95% confidence intervals for incidence of lung cancer and histologic types were estimated in relation to the allele score. The inverse-variance weighted method using summarised data of individual single nucleotide polymorphisms was applied to calculate the Mendelian randomisation estimates.The allele score accounted for 3.4% of the variation in serum 25(OH)D levels. There was no association between the allele score and lung cancer incidence overall, with HR 0.99 (95% CI 0.93–1.06) per allele score. A 25 nmol·L−1 increase in genetically determined 25(OH)D level was not associated with the incidence of lung cancer overall (Mendelian randomisation estimate HR 0.96, 95% CI 0.54–1.69) or any histologic type.Mendelian randomisation analysis did not suggest a causal association between 25(OH)D levels and risk of lung cancer overall or histologic types in this population-based cohort study.Mendelian randomisation study did not suggest causal association between serum 25-hydroxyvitamin D and lung cancer risk http://ow.ly/UOJ630jGVh1