%0 Journal Article %A Yi-Qian Sun %A Ben M. Brumpton %A Carolina Bonilla %A Sarah J. Lewis %A Stephen Burgess %A Frank Skorpen %A Yue Chen %A Tom I.L. Nilsen %A Pål Richard Romundstad %A Xiao-Mei Mai %T Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomisation analysis of the HUNT study %D 2018 %R 10.1183/13993003.00329-2018 %J European Respiratory Journal %P 1800329 %V 51 %N 6 %X We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D (25(OH)D) levels and incidence of lung cancer overall and histologic types.We performed a Mendelian randomisation analysis using a prospective cohort study in Norway, including 54 580 individuals and 676 incident lung cancer cases. A 25(OH)D allele score was generated based on the vitamin D-increasing alleles rs2282679, rs12785878 and rs10741657. Hazard ratios with 95% confidence intervals for incidence of lung cancer and histologic types were estimated in relation to the allele score. The inverse-variance weighted method using summarised data of individual single nucleotide polymorphisms was applied to calculate the Mendelian randomisation estimates.The allele score accounted for 3.4% of the variation in serum 25(OH)D levels. There was no association between the allele score and lung cancer incidence overall, with HR 0.99 (95% CI 0.93–1.06) per allele score. A 25 nmol·L−1 increase in genetically determined 25(OH)D level was not associated with the incidence of lung cancer overall (Mendelian randomisation estimate HR 0.96, 95% CI 0.54–1.69) or any histologic type.Mendelian randomisation analysis did not suggest a causal association between 25(OH)D levels and risk of lung cancer overall or histologic types in this population-based cohort study.Mendelian randomisation study did not suggest causal association between serum 25-hydroxyvitamin D and lung cancer risk http://ow.ly/UOJ630jGVh1 %U https://erj.ersjournals.com/content/erj/51/6/1800329.full.pdf