RT Journal Article SR Electronic T1 Tobacco smoke exposure in early life and adolescence in relation to lung function JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1702111 DO 10.1183/13993003.02111-2017 A1 Jesse D. Thacher A1 Erica S. Schultz A1 Jenny Hallberg A1 Ulrika Hellberg A1 Inger Kull A1 Per Thunqvist A1 Göran Pershagen A1 Per M. Gustafsson A1 Erik Melén A1 Anna Bergström YR 2018 UL http://erj.ersjournals.com/content/early/2018/04/26/13993003.02111-2017.abstract AB Maternal smoking during pregnancy is associated with impaired lung function among young children, but less is known about long-term effects and the impact of adolescents' own smoking. We investigated the influence of maternal smoking during pregnancy, secondhand smoke exposure, and adolescent smoking on lung function at age 16 years.The BAMSE birth cohort collected information on participant's tobacco smoke exposure through repeated questionnaires, and measured saliva cotinine concentrations at age 16. Participants performed spirometry and impulse oscillometry (IOS) at age 16 (n=2295).Exposure to maternal smoking during pregnancy was associated with reduced FEV1/FVC of −1.1% (95% CI −2.0 to −0.2). IOS demonstrated greater resistance at R5–20 Hz in participants exposed to maternal smoking during pregnancy. Adolescents who smoked had reduced FEV1/FVC ratios of −0.9% (95% CI −1.8 to −0.1) and increased resistance of 6.5 Pa·L–1·s in R5–20 Hz (95% CI: 0.7 to 12.2). Comparable associations for FEV1/FVC were observed for cotinine concentrations, using ≥12 ng·mL−1 as a cut-off for adolescent smoking.Maternal smoking during pregnancy was associated with lower FEV1/FVC ratios and increased airway resistance. Adolescent smoking also appears to be associated with reduced FEV1/FVC ratios and increased peripheral airway resistance.Maternal smoking in utero as well as teen smoking is associated with indices of airway obstruction at age 16 yearsFootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Thacher has nothing to disclose.Conflict of interest: Dr. Schultz has nothing to disclose.Conflict of interest: Dr. Hallberg has nothing to disclose.Conflict of interest: Dr. Hellberg has nothing to disclose.Conflict of interest: Dr. Kull has nothing to disclose.Conflict of interest: Dr. Thunqvist has nothing to disclose.Conflict of interest: Dr. Pershagen has nothing to disclose.Conflict of interest: Dr. Gustafsson has nothing to disclose.Conflict of interest: Dr. Melén has nothing to disclose.Conflict of interest: Dr. Bergström has nothing to disclose.