TY - JOUR T1 - Maximal exercise capacity in patients with obstructive sleep apnoea syndrome: A systematic review and meta-analysis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.02697-2017 SP - 1702697 AU - Monique Mendelson AU - Mathieu Marillier AU - Sébastien Bailly AU - Patrice Flore AU - Jean-Christian Borel AU - Isabelle Vivodtzev AU - Stéphane Doutreleau AU - Renaud Tamisier AU - Jean-Louis Pépin AU - Samuel Verges Y1 - 2018/01/01 UR - http://erj.ersjournals.com/content/early/2018/04/12/13993003.02697-2017.abstract N2 - Maximal aerobic capacity is a strong health predictor and peak oxygen consumption (VO2peak) is considered a reflection of total body health. No systematic reviews or meta-analysis’ to date have synthesised the existing data regarding VO2peak in patients with obstructive sleep apnoea (OSA).A systematic review of English and French articles using Pubmed/Medline and Embase included studies assessing VO2peak of OSA patients in mL·kg−1·min−1 compared with controls or in % predicted. Two independent reviewers analysed the studies, extracted the data and assessed the quality of evidence.Mean VO2peak expressed in mL·kg−1·min−1 was significantly lower in patients with OSA when compared with controls (mean difference=−2.7 mL·kg−1·min−1; p<0.001; n=850). This reduction in VO2peak was found to be larger in non-obese patients (BMI<30 kg·m−2). Mean VO2peak in % predicted was 90.7±21.0% in OSA patients (n=643).OSA patients present reduced maximal aerobic capacity, which can be associated with increased cardiovascular risks and reduced survival in certain patient subgroups. Maximal exercise testing can be useful to characterise functional limitation and to evaluate health status in OSA patients.Registration # CRD42017057319Maximal exercise capacity as a reflection of total body health is reduced in patients with obstructive sleep apnoeaFootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Mendelson has nothing to disclose.Conflict of interest: Dr. Marillier has nothing to disclose.Conflict of interest: Dr. BAILLY has nothing to disclose.Conflict of interest: Dr. FLORE has nothing to disclose.Conflict of interest: Dr. Borel reports grants and personal fees from Philips, other from AGIR à dom (home care provider), personal fees and other from RESMED, other from NOMICS , outside the submitted work; .Conflict of interest: Dr. Vivodtzev has nothing to disclose.Conflict of interest: Dr. doutreleau has nothing to disclose.Conflict of interest: Dr. Tamisier has nothing to disclose.Conflict of interest: Dr. Pépin reports grants from Resmed, during the conduct of the study; grants and personal fees from Resmed, grants and personal fees from Philips, grants from Fisher & Paykel, grants and personal fees from Sefam, grants from Astra Zeneca, grants and personal fees from Agir à dom. , personal fees from Elevie, grants and personal fees from Vitalaire, personal fees from Bohringer, outside the submitted work; .Conflict of interest: Dr. Verges has nothing to disclose. ER -