TY - JOUR T1 - <em>In vivo</em> growth of 60 non-screening detected lung cancers: a computed tomography study JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.02183-2017 VL - 51 IS - 4 SP - 1702183 AU - Onno M. Mets AU - Kaman Chung AU - Pieter Zanen AU - Ernst T. Scholten AU - Wouter B. Veldhuis AU - Bram van Ginneken AU - Mathias Prokop AU - Cornelia M. Schaefer-Prokop AU - Pim A. de Jong Y1 - 2018/04/01 UR - http://erj.ersjournals.com/content/51/4/1702183.abstract N2 - Current pulmonary nodule management guidelines are based on nodule volume doubling time, which assumes exponential growth behaviour. However, this is a theory that has never been validated in vivo in the routine-care target population. This study evaluates growth patterns of untreated solid and subsolid lung cancers of various histologies in a non-screening setting.Growth behaviour of pathology-proven lung cancers from two academic centres that were imaged at least three times before diagnosis (n=60) was analysed using dedicated software. Random-intercept random-slope mixed-models analysis was applied to test which growth pattern most accurately described lung cancer growth. Individual growth curves were plotted per pathology subgroup and nodule type.We confirmed that growth in both subsolid and solid lung cancers is best explained by an exponential model. However, subsolid lesions generally progress slower than solid ones. Baseline lesion volume was not related to growth, indicating that smaller lesions do not grow slower compared to larger ones.By showing that lung cancer conforms to exponential growth we provide the first experimental basis in the routine-care setting for the assumption made in volume doubling time analysis.Lung cancers in vivo conform to an exponential growth pattern http://ow.ly/ps0L30jN1LD ER -