TY - JOUR T1 - LONG TERM BEDAQUILINE-RELATED TREATMENT OUTCOMES IN PATIENTS WITH EXTENSIVELY DRUG RESISTANT TUBERCULOSIS FROM SOUTH AFRICA JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00544-2018 SP - 1800544 AU - Olatunde Olayanju AU - Jason Limberis AU - Aliasgar Esmail AU - Suzette Oelofse AU - Phindile Gina AU - Elize Pietersen AU - Mohammed Fadul AU - Rob Warren AU - Keertan Dheda Y1 - 2018/01/01 UR - http://erj.ersjournals.com/content/early/2018/04/05/13993003.00544-2018.abstract N2 - The persistence of the multi-drug-resistant tuberculosis (MDR-TB) epidemic threatens to destabilise TB control [1, 2]. MDR-TB is defined as a TB strain with resistance to at least isoniazid and rifampicin. In 2016 ∼600 000 new cases of MDR- or rifampicin-resistant TB were estimated to have occurred globally. Detection rates have more than doubled in several countries such as China, India and Russia in the last several years, and almost 20% of Mycobacterium tuberculosis isolates globally are now resistant to at least one first or second line anti-TB drug [3]. Approximately 10% of global MDR-TB strains are thought to be extensively drug-resistant TB (XDR-TB), which is MDR-TB with additional resistance to a fluoroquinolone and a second line injectable drug.Bedaquiline remarkably improved treatment-related outcomes in patients with extensively drug resistant tuberculosis.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Olayanju has nothing to disclose.Conflict of interest: Dr. Limberis has nothing to disclose.Conflict of interest: Dr. Esmail has nothing to disclose.Conflict of interest: Dr. Oelofse has nothing to disclose.Conflict of interest: Dr. Gina has nothing to disclose.Conflict of interest: Dr. Pietersen has nothing to disclose.Conflict of interest: Mr. Fadul has nothing to disclose.Conflict of interest: Dr. Warren has nothing to disclose.Conflict of interest: Dr. Dheda has nothing to disclose. ER -