PT - JOURNAL ARTICLE AU - Nicolas Coquoz AU - Daniel Weilenmann AU - Daiana Stolz AU - Vladimir Popov AU - Andrea Azzola AU - Jean-Marc Fellrath AU - Hans Stricker AU - Alberto Pagnamenta AU - Sebastian Ott AU - Silvia Ulrich AU - Sandor Györik AU - Jérôme Pasquier AU - John-David Aubert TI - Multicentre observational screening survey for the detection of CTEPH following pulmonary embolism AID - 10.1183/13993003.02505-2017 DP - 2018 Apr 01 TA - European Respiratory Journal PG - 1702505 VI - 51 IP - 4 4099 - http://erj.ersjournals.com/content/51/4/1702505.short 4100 - http://erj.ersjournals.com/content/51/4/1702505.full SO - Eur Respir J2018 Apr 01; 51 AB - Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe complication of pulmonary embolism. Its incidence following pulmonary embolism is debated. Active screening for CTEPH in patients with acute pulmonary embolism is yet to be recommended.This prospective, multicentre, observational study (Multicentre Observational Screening Survey for the Detection of Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Following Pulmonary Embolism (INPUT on PE); ISRCTN61417303) included patients with acute pulmonary embolism from 11 centres in Switzerland from March 2009 to November 2016. Screening for possible CTEPH was performed at 6, 12 and 24 months using a stepwise algorithm that included a dyspnoea phone-based survey, transthoracic echocardiography, right heart catheterisation and radiological confirmation of CTEPH.Out of 1699 patients with pulmonary embolism, 508 patients were assessed for CTEPH screening over 2 years. CTEPH incidence following pulmonary embolism was 3.7 per 1000 patient-years, with a 2-year cumulative incidence of 0.79%. The Swiss pulmonary hypertension registry consulted in December 2016 did not report additional CTEPH cases in these patients. The survey yielded 100% sensitivity and 81.6% specificity. The second step echocardiography in newly dyspnoeic patients showed a negative predictive value of 100%.CTEPH is a rare but treatable disease. A simple and sensitive way for CTEPH screening in patients with acute pulmonary embolism is recommended.Chronic thromboembolic pulmonary hypertension is an uncommon disease; active screening of CTEPH in patients after acute pulmonary embolism should be considered http://ow.ly/mmFI30j3Lca