PT - JOURNAL ARTICLE AU - Cheon Tae Kim AU - Tae-Ok Kim AU - Hong-Joon Shin AU - Young Chun Ko AU - Yeong Hun Choe AU - Hak-Ryul Kim AU - Yong-Soo Kwon TI - Bedaquiline and delamanid for the treatment of multidrug-resistant tuberculosis: a multicentre cohort study in Korea AID - 10.1183/13993003.02467-2017 DP - 2018 Mar 01 TA - European Respiratory Journal PG - 1702467 VI - 51 IP - 3 4099 - http://erj.ersjournals.com/content/51/3/1702467.short 4100 - http://erj.ersjournals.com/content/51/3/1702467.full SO - Eur Respir J2018 Mar 01; 51 AB - Relatively little is known about the efficacy and safety of the programmatic use of bedaquiline and delamanid in multidrug-resistant tuberculosis (MDR-TB) treatment.This study evaluated 61 patients with MDR-TB treated with bedaquiline (n=39), delamanid (n=11) or both, either sequentially (n=10) or in coadministration (n=1), for >1 month, combined with a World Health Organization-recommended regimen.Of these, 49 (80.3%) were male and 12 (19.7%) were female. The median (interquartile range (IQR)) age was 53 (38.5–61.0) years. 42 (68.9%) patients had fluoroquinolone-resistant MDR-TB and 16 (26.2%) had extensively drug-resistant TB. The median (IQR) duration of treatment with bedaquiline and/or delamanid was 168 (166.5–196.5) days, with 33 (54.1%) receiving linezolid for a median (IQR) of 673 (171–736) days. Of the 55 patients with positive sputum cultures at the start of bedaquiline and/or delamanid treatment, 39 (70.9%) achieved sputum culture conversion within a median of 119 days. Treatment was halted in four patients (6.6%) because of prolonged Fridericia's corrected QT interval.Bedaquiline and delamanid were effective and safe for treating MDR-TB, with initial evidence of sequential administration of these two drugs as a viable treatment strategy for patients when an adequate treatment regimen cannot be constructed.Bedaquiline and delamanid are effective and safe for MDR-TB treatment when combined with @WHO recommended regimens http://ow.ly/Xw8O30iqa0j